Emerging Biomarkers in Acute Coronary Syndromes - A Pathophysiologic Perspective

Heart Lung Circ. 2022 Jun;31(6):779-786. doi: 10.1016/j.hlc.2022.01.015. Epub 2022 Mar 10.

Abstract

Diagnosis and prognostication in acute coronary syndromes (ACS) is achieved using a combination of clinical factors and biomarkers, notably cardiac troponin and B type natriuretic peptide and its N terminal fragment NT-proBNP. However, there are numerous biomarkers that have been shown to be associated with ACS, with variable incremental utility. This brief review focusses on some promising emerging biomarkers in ACS, discussed according to pathophysiologic mechanism, as well as diagnostic and prognostic utility.

Keywords: Acute coronary syndrome; Biomarker; Pathophysiology; Prognosis; Risk prediction.

Publication types

  • Review

MeSH terms

  • Acute Coronary Syndrome* / diagnosis
  • Biomarkers
  • Humans
  • Natriuretic Peptide, Brain
  • Peptide Fragments
  • Predictive Value of Tests
  • Prognosis
  • Risk Assessment

Substances

  • Biomarkers
  • Peptide Fragments
  • Natriuretic Peptide, Brain