Benzobisthiadiazole and Its Derivative-Based Semiconducting Polymer Nanoparticles for Second Near-Infrared Photoacoustic Imaging

Xuelong Huang; Ning Lan; Yanfeng Zhang; Wei Zeng; Haifeng He; Xiuhong Liu

doi:10.3389/fchem.2022.842712

Benzobisthiadiazole and Its Derivative-Based Semiconducting Polymer Nanoparticles for Second Near-Infrared Photoacoustic Imaging

Front Chem. 2022 Feb 24:10:842712. doi: 10.3389/fchem.2022.842712. eCollection 2022.

Authors

Xuelong Huang¹, Ning Lan¹, Yanfeng Zhang¹, Wei Zeng¹, Haifeng He², Xiuhong Liu²

Affiliations

¹ Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Key Laboratory of Biomaterials and Biofabrication in Tissue Engineering of Jiangxi Province, College of Medical Information Engineering, Gannan Medical University, Ganzhou, China.
² Jiangxi Engineering Laboratory of Waterborne Coating, School of Chemistry and Chemical Engineering, Jiangxi Science and Technology Normal University, Nanchang, China.

Abstract

Photoacoustic (PA) imaging has received more and more attention on disease diagnosis and fundamental scientific research. It is still challenging to amplify their imaging ability and reduce the toxicity of inorganic materials and exogenous contrast agents. Semiconducting polymer nanoparticles (SPNs), as a new type of contrast agent, have the advantages of low toxicity, flexible structure adjustment, good photostability, and excellent photothermal conversion efficiency. SPNs containing benzo(1,2-c;4,5-c')bis(1,2,5)thiadiazole (BBT) units, as the most classic second near-infrared window (NIR-II, 1,000-1700 nm) PA contrast agents, can achieve light absorption in the NIR-II region, thereby effectively reducing light loss in biological tissues and improving imaging resolution. This mini review summarizes the recent advances in the design strategy of BBT and its derivative-based semiconducting polymer nanoparticles for second near-infrared photoacoustic imaging. The evolution process of BBT blocks provides a unique perspective for the design of high-performance NIR-II PA contrast agents.

Keywords: benzobisthiadiazole; nanoparticles; near-infrared-II; photoacoustic imaging; semiconducting polymer; thiadiazolobenzotriazole; thiadiazoloquinoxaline.

Publication types

Review