Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

Front Immunol. 2022 Feb 25:13:812431. doi: 10.3389/fimmu.2022.812431. eCollection 2022.

Abstract

Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to inflammation and tumor sites. Although a variety of chemokines have been well studied in various diseases, there is no comprehensive review presenting the roles of all known chemokine ligands of CCR2 (CCL2, CCL7, CCL8, CCL12, CCL13, CCL16, and PSMP) in liver disease, and this review aims to fill this gap. The introduction of each chemokine includes its discovery, its corresponding chemotactic receptors, physiological functions and roles in inflammation and tumors, and its impact on different immune cell subgroups.

Keywords: CCL2; CCR2; PSMP; chemokine; hepatocellular carcinoma; macrophage.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chemokines
  • Fibrosis
  • Humans
  • Inflammation
  • Ligands
  • Liver Diseases*
  • Neoplasms*
  • Receptors, CCR2

Substances

  • CCR2 protein, human
  • Chemokines
  • Ligands
  • Receptors, CCR2