Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient

Tomas Arpas; Hana Jelinkova; Stepan Hrabovsky; Martina Orsulova; Zuzana Vrzalova; Veronika Navrkalova; Eva Brhelova; Lenka Bryjova; Alena Bulikova; Eva Ondrouskova; Marketa Sejnohova; Frantisek Folber; Petra Sedová; Jiri Mayer; Sarka Pospisilova; Marie Jarosova; Michael Doubek

doi:10.1002/ccr3.5545

Very rare near-haploid acute lymphoblastic leukemia resistant to immunotherapy and CAR-T therapy in 19-year-old male patient

Clin Case Rep. 2022 Mar 3;10(3):e05545. doi: 10.1002/ccr3.5545. eCollection 2022 Mar.

Authors

Tomas Arpas¹, Hana Jelinkova², Stepan Hrabovsky¹, Martina Orsulova¹, Zuzana Vrzalova^{2

3}, Veronika Navrkalova², Eva Brhelova², Lenka Bryjova², Alena Bulikova^{1

4}, Eva Ondrouskova², Marketa Sejnohova², Frantisek Folber¹, Petra Sedová¹, Jiri Mayer¹, Sarka Pospisilova^{2

3

5}, Marie Jarosova^{2

5}, Michael Doubek^{1

3

5}

Affiliations

¹ Department of Internal Medicine, Hematology and Oncology University Hospital and Faculty of Medicine Brno Czechia.
² Center of Molecular Biology and Genetics Department of Internal Medicine, Hematology and Oncology University Hospital and Faculty of Medicine Brno Czechia.
³ Central European Institute of Technology (CEITEC) Masaryk University Brno Czechia.
⁴ Department of Clinical Hematology University Hospital Brno Czechia.
⁵ Department of Medical Genetics and Genomics University Hospital and Faculty of Medicine Brno Czechia.

Abstract

Near-haploid acute lymphoblastic leukemia is rare subgroup of the disease, which is very important due to very poor prognosis and resistance to treatment including novel monoclonal antibodies and CAR-T therapy.

Keywords: CAR‐T therapy; acute lymphoblastic leukemia; blinatumomab; inotuzumab ozogamicin; near‐haploid.

Publication types

Case Reports