SIRT6 serves as a polyhedron in glycolytic metabolism and ageing-related diseases

Zhixiao Yuan; Yutian Zeng; Yao Tian; Shuai Wang; Binyan Hong; Mingyao Yang

doi:10.1016/j.exger.2022.111765

SIRT6 serves as a polyhedron in glycolytic metabolism and ageing-related diseases

Exp Gerontol. 2022 Jun 1:162:111765. doi: 10.1016/j.exger.2022.111765. Epub 2022 Mar 9.

Authors

Zhixiao Yuan¹, Yutian Zeng¹, Yao Tian¹, Shuai Wang¹, Binyan Hong¹, Mingyao Yang²

Affiliations

¹ Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, Sichuan, China.
² Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, Sichuan, China. Electronic address: yangmingyao@sicau.edu.cn.

PMID: 35278642
DOI: 10.1016/j.exger.2022.111765

Abstract

Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide (NAD⁺)-dependent enzyme. It is a novel member of the sirtuin family that has been shown to have an important role in various molecular pathways in glycolysis, cancer, and neurodegenerative responses. Recently, SIRT6 has emerged as a prominent research issue because its biochemical activity and regulation are possibly associated with human metabolism and disease. In this review, we summarized the connection between SIRT6 and glycolytic metabolism; discussed recent developments in the involvement of SIRT6 in a variety of life-threatening illnesses, including cancer, neurodegenerative diseases and cardiovascular disease; and explored possible treatment approaches for those diseases with SIRT6. This review provides insights into the role of SIRT6 in disease.

Keywords: Ageing; Cancer; Metabolism; Neurodegenerative diseases; SIRT6.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging
Glycolysis
Humans
Neoplasms* / metabolism
Neurodegenerative Diseases*
Sirtuins* / metabolism

Substances

SIRT6 protein, human
Sirtuins