Kinase Sensing Based on Protein Interactions at the Catalytic Site

Chemistry. 2022 Mar 22;28(17):e202200655. doi: 10.1002/chem.202200655. Epub 2022 Mar 11.

Abstract

Invited for the cover of this issue is Assaf Friedler, Shlomo Yitzchaik and co-workers at the Hebrew University of Jerusalem and the Academia Sinica. The image depicts a new approach for electrochemical kinase sensing that does not rely on phosphorylation. The kinase binds a peptide layer, which undergoes rearrangement, resulting in the permeation of redox-active species through the layer and electrochemical sensing. Read the full text of the article at 10.1002/chem.202104227.

MeSH terms

  • Catalytic Domain
  • Humans
  • Peptides*

Substances

  • Peptides