PubMed, ScienceDirect, Cochrane, Embase, Scopus, China National Knowledge Infrastructure (CNKI), Chinese Weipu, and Wanfang databases were searched to evaluate the effects of probiotics supplements on gastric cancer-related inflammatory factors. Parallel randomized controlled trials (RCTs) assessing the effects of prebiotics supplement on gastric cancer patients were included in the review. Compared with routine nutrition, meta-analysis shows that probiotics supplements reduce gastric cancer-related inflammation levels by mostly increasing the levels of cluster of differentiation 4+ and greatly reducing the levels of interleukin-6. Probiotics supplements can control the inflammatory response in cancer patients and may be a potential approach for controlling inflammatory levels in the patients. However, a larger population is needed for further study because of a certain degree of heterogeneity in this review. PRACTICAL APPLICATIONS: The effects of probiotics (Bifidobacterium, Lactobacillus, and Streptococcus species) on the gastric cancer-related inflammation were investigated. Probiotics can reduce gastric cancer-related inflammation levels more effectively by increasing the levels of cluster of differentiation 4+ and greatly reducing the levels of interleukin-6. The study provides some theoretical basis for controlling cancer-related inflammation responses in the patients using probiotics.
Keywords: gastric cancer; inflammation; meta-analysis; probiotics.
© 2022 Wiley Periodicals LLC.