Association of early-onset breast cancer with body mass index, menarche, and menopause in Taiwan

Pei-Jing Yang; Ming-Feng Hou; Fu Ou-Yang; Eing-Mei Tsai; Tsu-Nai Wang

doi:10.1186/s12885-022-09361-2

Association of early-onset breast cancer with body mass index, menarche, and menopause in Taiwan

BMC Cancer. 2022 Mar 11;22(1):259. doi: 10.1186/s12885-022-09361-2.

Authors

Pei-Jing Yang¹, Ming-Feng Hou^{2

3}, Fu Ou-Yang², Eing-Mei Tsai^{4

5}, Tsu-Nai Wang^{6

7}

Affiliations

¹ Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
² Division of Breast Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, 80756, Taiwan.
³ Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
⁴ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.
⁵ Department of Obstetrics and Gynecology, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, 80756, Taiwan.
⁶ Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. wangtn@kmu.edu.tw.
⁷ Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, 80708, Taiwan. wangtn@kmu.edu.tw.

Abstract

Background: The trend of women suffering from early-onset breast cancer is increasing in Taiwan. The association of early-onset breast cancer with body mass index (BMI), menarche, and menopausal status has focused interest on the field of cancer epidemiology; however, few studies have explored the interaction of these factors on early-onset risk. This study aimed to estimate the interaction effects of BMI, menarche, and menopausal status on 40-year-old early-onset breast cancer.

Methods: Breast cancer patients were recruited from Kaohsiung Medical University Chung-Ho Memorial Hospital from 2013 to 2020. Multivariable logistic regression was used to estimate odds ratios (ORs) for early-onset breast cancer risk associated with menarcheal age stratified by sociodemographic factors and for the interaction between BMI and menopausal status on early-onset risk.

Results: A total of 775 participants were divided into 131 early-onset cases (≤ 40 years) and 644 late-onset cases (> 40 years). Compared to the age of 13 years at menarche, the age ≤ 11 years was significantly positively associated (OR: 2.62, 95% CI: 1.38-4.97) and ≥ 16 years was negatively associated (OR: 0.13, 95% CI: 0.03-0.53) with 40-year-old early-onset breast cancer respectively. In an adjusted model, the status of BMI < 24 and premenopause had 1.76- and 4.59-fold risk of early-onset breast cancer respectively. Especially in BMI < 24 status, premenopause also had a 6.47-fold early-onset risk and the early-onset risk increased by a significant amount per one year younger at menarche (aOR: 1.26, 95% CI: 1.03-1.55). There was also a positive interaction effect on an additive scale between BMI and menopausal status on early-onset breast cancer (RERI_OR = 4.62, P_interaction = 0.057). Compared to both BMI ≥ 24 and peri-/postmenopausal status, both the status of BMI < 24 and premenopause were associated with early-onset breast cancer (aOR: 7.16, 95% CI: 3.87-13.25).

Conclusions: This study suggests that the status of BMI < 24 and premenopause were associated with an increased risk of early-onset breast cancer and there was a positive interaction on an additive scale. Understanding how obesity and menopausal status affect early-onset breast cancer is important for drafting preventive measures for early-onset breast cancer in Taiwan.

Keywords: BMI; Breast cancer; Early-onset; Epidemiology; Interaction; Menarche; Menopause.

MeSH terms

Adult
Age of Onset
Body Mass Index
Breast Neoplasms / epidemiology*
Cross-Sectional Studies
Female
Humans
Menarche*
Middle Aged
Premenopause*
Risk Factors
Taiwan / epidemiology