Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction

Junjie Zou; Dongping Yuan; Jin Yang; Yun Yu

doi:10.3389/fnut.2022.831485

Effects of Diosmin on Vascular Leakage and Inflammation in a Mouse Model of Venous Obstruction

Front Nutr. 2022 Feb 22:9:831485. doi: 10.3389/fnut.2022.831485. eCollection 2022.

Authors

Junjie Zou¹, Dongping Yuan², Jin Yang³, Yun Yu²

Affiliations

¹ First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
² School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
³ Department of Vascular Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Abstract

At present, iliac vein compression syndrome (IVCS) plagues countless people, posing a significant economic and social burden. The progress of current IVCS-related research is slow owing to the limitations of animal models. In this study, we generated a mouse model of iliac vein stenosis (IVS) to monitor the effects of IVCS on venous function, such as increased vascular leakage, the expression of adhesion molecules, and elevated inflammation factors. Diosmin, a widely used clinical bioactive ingredient, was administered to confirm its therapeutic effects on the IVS mouse model. The results revealed that diosmin manifested therapeutic improvement in the IVS mouse model. In addition, we verified that the IVS mouse model is a stable and reproducible animal model for pathophysiological studies. High-purity diosmin can be beneficial to venous dysfunction and hence provides a more effective treatment option for venous diseases.

Keywords: diosmin; iliac vein compression syndrome; iliac vein stenosis; inflammation; venous permeability.