Expression of serum autophagy-related protein P62 in patients with severe pancreatitis and its correlation with prognosis

Yulong Luo; Lin Fan; Lixing Huang; Canhui Ouyang; Qiuping Zhu

Expression of serum autophagy-related protein P62 in patients with severe pancreatitis and its correlation with prognosis

Am J Transl Res. 2022 Feb 15;14(2):1376-1383. eCollection 2022.

Authors

Yulong Luo¹, Lin Fan¹, Lixing Huang¹, Canhui Ouyang¹, Qiuping Zhu²

Affiliations

¹ Department of Gastroenterology, First Affiliated Hospital of Gannan Medical University Ganzhou 341000, Jiangxi Province, China.
² Department of Critical Care Medicine, First Affiliated Hospital of Gannan Medical University Ganzhou 341000, Jiangxi Province, China.

PMID: 35273740
PMCID: PMC8902530

Abstract

Objective: This study was designed to investigate the expression of serum autophagy-related protein P62 in patients with severe acute pancreatitis (AP) and its correlation with prognosis.

Methods: Eighty patients with AP treated in the First Affiliated Hospital of Gannan Medical University from January 2020 to January 2021 were enrolled as study subjects in this retrospective analysis, and they were placed into the mild AP group (n=52) or the severe AP group (n=28). According to clinical outcomes, these 80 patients were divided into a good prognosis group (GP group, n=51, surviving without serious complications such as organ failure) and a poor prognosis group (PP group, n=29, death or developing organ failure). The differences in C-reactive protein (CRP), P62 and the Acute Physiology and Chronic Health Evaluation II (APACHE-II) were compared upon admission. The changes of CRP, P62 and APACHE-II within 1-7 h after admission were dynamically analyzed in the two groups. Spearman correlation analysis was performed to explore the correlation between P62 and APACHE-II scores, and the receiver operating characteristic (ROC) curve of P62 related to poor AP outcome was plotted.

Results: CRP, P62 and APACHE-II in the mild AP group were significantly higher than those in the severe AP group, and these in the PP group were also significantly higher than those in the GP group (P<0.05). Dynamic monitoring showed that within 1-7 h after admission, CRP, P62, and APACHE-II in the severe AP group were significantly higher than those in the mild AP group (P<0.05), and these in the PP group were significantly higher than those in the GP group (P<0.05). Spearman correlation analysis showed that P62 level was significantly positively correlated with both CRP and APACHE-II (r=0.9331, r=0.9500, P<0.0001). ROC curve showed that AUC of P62 was 0.9570 in AP patients with poor prognosis (95% CI=0.8939-1.000, P<0.0001).

Conclusion: Serum autophagy-related protein P62 was closely related to the condition and prognosis of AP patients, and P62 could be used as a potential indicator to assess the condition and prognosis of AP patients.

Keywords: Autophagy-related protein; P62; acute pancreatitis; expression; prognosis.