Tfh cells induce intratumoral tertiary lymphoid structures

Lisa Schmidleithner; Markus Feuerer

doi:10.1016/j.it.2022.02.010

Tfh cells induce intratumoral tertiary lymphoid structures

Trends Immunol. 2022 Apr;43(4):274-276. doi: 10.1016/j.it.2022.02.010. Epub 2022 Mar 8.

Authors

Lisa Schmidleithner¹, Markus Feuerer²

Affiliations

¹ Division of Immunology, Leibniz Institute for Immunotherapy (LIT), 93053 Regensburg, Germany; Chair for Immunology, University Regensburg, 93053 Regensburg, Germany.
² Division of Immunology, Leibniz Institute for Immunotherapy (LIT), 93053 Regensburg, Germany; Chair for Immunology, University Regensburg, 93053 Regensburg, Germany. Electronic address: markus.feuerer@ukr.de.

PMID: 35272934
DOI: 10.1016/j.it.2022.02.010

Abstract

Tertiary lymphoid structures (TLS) are highly organized ectopic structures found in nonlymphoid organs under chronic inflammatory conditions, including cancer. A recent study by Chaurio et al. reports that repression of Satb1 in CD4⁺ T cells can lead to increased Tfh cell differentiation, driving intratumoral TLS formation, resulting in reduced tumor growth in mice.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Cell Differentiation
Humans
Matrix Attachment Region Binding Proteins*
Mice
Neoplasms*
T Follicular Helper Cells
Tertiary Lymphoid Structures* / pathology

Substances

Matrix Attachment Region Binding Proteins
SATB1 protein, human