Undifferentiated high-grade pleomorphic sarcoma of the colon: a rare case report and literature review

BMC Gastroenterol. 2022 Mar 10;22(1):115. doi: 10.1186/s12876-022-02189-x.

Abstract

Background: Undifferentiated pleomorphic sarcoma (UPS), also known as malignant fibrous histiocytoma (MFH), hardly originates from the colorectum.

Case presentation: We reported a 65-year-old female presented with UPS in the descending colon. Computed tomography (CT) revealed an irregularly thickened descending colon. On colonoscopy examination, an ulcerative tumour was identified. The patient received radical resection of the left colon and partial enterectomy. The resected tumor was ulcerative, 10 cm × 8 cm × 5 cm in size, and infiltrated the serosa layer. Postsurgical pathology showed that the tumor was high-graded UPS in the colon with large amounts of necrotic tissues.

Conclusions: UPS in the large intestine is a rare malignant tumor with a poor prognosis and unknown pathogenesis. The main treatment for UPS is early complete resection. Postsurgery adjuvant radiotherapy or chemotherapy can be attempted.

Keywords: Case report; Colon; Malignant fibrous histiocytoma; Undifferentiated pleomorphic sarcoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Colon / pathology
  • Female
  • Histiocytoma, Malignant Fibrous* / diagnostic imaging
  • Histiocytoma, Malignant Fibrous* / surgery
  • Humans
  • Sarcoma* / diagnostic imaging
  • Sarcoma* / surgery
  • Tomography, X-Ray Computed