First report of suspected glycogen storage disease type 1a occurring in an adult dog

K E Rolph; S M Cavanaugh; H E Wilson

doi:10.1111/jsap.13494

First report of suspected glycogen storage disease type 1a occurring in an adult dog

J Small Anim Pract. 2022 Sep;63(9):713-716. doi: 10.1111/jsap.13494. Epub 2022 Mar 10.

Authors

K E Rolph¹, S M Cavanaugh¹, H E Wilson²

Affiliations

¹ Clinical Sciences Department and Center for Integrative Mammalian Research, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis.
² Langford Vets, University of Bristol, Bristol, BS40 5DU, UK.

PMID: 35272391
DOI: 10.1111/jsap.13494

Abstract

A 4-year-old female border collie was presented with haemoabdomen following the rupture of a hepatocellular carcinoma. After referral for ongoing elevation of alanine aminotransferase and alkaline phosphatase, the dog was found to have marked vacuolar hepatopathy due to glycogen accumulation within the liver, fasting hypoglycaemia and hyperlactataemia, and a negative response to glucagon stimulation testing. These changes were strongly suggestive of glycogen storage disease type 1a. Based on our literature search, this report documents the first adult canine to be diagnosed with suspected glycogen storage disease type 1a.

Publication types

Case Reports

MeSH terms

Animals
Carcinoma, Hepatocellular* / veterinary
Dog Diseases* / diagnosis
Dogs
Female
Glycogen Storage Disease Type I* / complications
Glycogen Storage Disease Type I* / diagnosis
Glycogen Storage Disease Type I* / veterinary
Liver
Liver Neoplasms* / veterinary

Supplementary concepts

Hepatorenal form of glycogen storage disease