Clinical implications of miR-223 in allergic conjunctivitis and related factors affecting disease recurrence

Abstract

This study aims to explore the clinical implications of miR-223 in allergic conjunctivitis (AC) and the related factors affecting disease recurrence. 47 AC patients and 58 healthy controls were enrolled to measure miR-223 expression level, serum level of inflammatory mediators, and the correlation between miR-223 and inflammatory mediators. Subsequently, AC patients were followed up for six months to record disease recurrence and explore the risk factors affecting disease recurrence. Compared to the healthy controls, the miR-223 level was lower, while inflammatory cytokines and immunoglobulins levels were higher in AC patients. There was a negative correlation of miR-223 with inflammatory cytokines and immunoglobulins. Also, miR-223 was evidently lower in AC recurrence patients than those without recurrence. Moreover, family history, pet-keeping, and other allergic histories were among the risk factors contributing to AC recurrence. These results indicate that miR-223 plays an important role in the pathology of allergic conjunctivitis.

Keywords: Allergic conjunctivitis; Immunoglobulin; Inflammation; Recurrence; miR-223.