Personalized pathology test for Cardio-vascular disease: Approximate Bayesian computation with discriminative summary statistics learning

PLoS Comput Biol. 2022 Mar 10;18(3):e1009910. doi: 10.1371/journal.pcbi.1009910. eCollection 2022 Mar.

Abstract

Cardio/cerebrovascular diseases (CVD) have become one of the major health issue in our societies. But recent studies show that the present pathology tests to detect CVD are ineffectual as they do not consider different stages of platelet activation or the molecular dynamics involved in platelet interactions and are incapable to consider inter-individual variability. Here we propose a stochastic platelet deposition model and an inferential scheme to estimate the biologically meaningful model parameters using approximate Bayesian computation with a summary statistic that maximally discriminates between different types of patients. Inferred parameters from data collected on healthy volunteers and different patient types help us to identify specific biological parameters and hence biological reasoning behind the dysfunction for each type of patients. This work opens up an unprecedented opportunity of personalized pathology test for CVD detection and medical treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bayes Theorem
  • Cardiovascular Diseases* / diagnosis
  • Humans
  • Vascular Diseases*

Grants and funding

RD is funded by EPSRC (grant nos. EP/V025899/1, EP/T017112/1) and NERC (grant no. NE/T00973X/1). BC has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 823712 (CompBioMed2 project). KZB has received funding from CHU de Charleroi, the Fonds de la Chirurgie Cardiaque and the Fonds pour la Recherche Médicale en Hainaut. In addition, this work was funded under the embedded CSE programme of the ARCHER2 UK National Supercomputing Service (http://www.archer2.ac.uk) (to RD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.