Light-Addressable Potentiometric Sensors in Microfluidics

Xueliang Li; Shibin Liu; Jie Tan; Chunsheng Wu

doi:10.3389/fbioe.2022.833481

Light-Addressable Potentiometric Sensors in Microfluidics

Front Bioeng Biotechnol. 2022 Feb 21:10:833481. doi: 10.3389/fbioe.2022.833481. eCollection 2022.

Authors

Xueliang Li¹, Shibin Liu², Jie Tan², Chunsheng Wu³

Affiliations

¹ School of Mechanical and Electrical Engineering, Zhoukou Normal University, Zhoukou, China.
² College of Electronics and Information, Northwestern Polytechnical University, Xi'an, China.
³ Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, China.

Abstract

The light-addressable potentiometric sensor (LAPS) is an electrochemical sensor based on the field-effect principle of semiconductors. It is able to sense the change of Nernst potential on the sensor surface, and the measuring area can be controlled by the illumination of a movable light. Due to the unique light-addressable ability of the LAPS, the chemical imaging system constructed with the LAPS can realize the two-dimensional image distribution detection of chemical/biomass. In this review, the advantages of the LAPS as a sensing unit of the microelectrochemical analysis system are summarized. Then, the most recent advances in the development of the LAPS analysis system are explained and discussed. In particular, this review focused on the research of ion diffusion, enzymatic reaction, microbial metabolism, and droplet microfluidics using the LAPS analysis system. Finally, the development trends and prospects of the LAPS analysis system are illustrated.

Keywords: biosensors; chemical sensors; light-addressable potentiometric sensor; microfluidics; micropump.

Publication types

Review