In Vitro Disease Models for Understanding Psoriasis and Atopic Dermatitis

Roudin Sarama; Priya K Matharu; Yousef Abduldaiem; Mab P Corrêa; Cristiane D Gil; Karin V Greco

doi:10.3389/fbioe.2022.803218

In Vitro Disease Models for Understanding Psoriasis and Atopic Dermatitis

Front Bioeng Biotechnol. 2022 Feb 21:10:803218. doi: 10.3389/fbioe.2022.803218. eCollection 2022.

Authors

Roudin Sarama¹, Priya K Matharu¹, Yousef Abduldaiem^{1

2}, Mab P Corrêa³, Cristiane D Gil⁴, Karin V Greco^{1

2}

Affiliations

¹ Research and Development Department, The Griffin Institute, Harrow, United Kingdom.
² Division of Surgery and Interventional Science, University College London (UCL), London, United Kingdom.
³ Programa de Pós-Graduação Em Biociências, Instituto de Biociências Letras e Ciências Exatas, Universidade Estadual Paulista (UNESP), São José, Brazil.
⁴ Departamento de Morfologia e Genética, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São José, Brazil.

Abstract

Psoriasis (PS) and Atopic Dermatitis (AD) are two of the most prevalent inflammatory skin diseases. Dysregulations in the immune response are believed to play a crucial role in the pathogenesis of these conditions. Various parallels can be drawn between the two disorders, as they are both genetically mediated, and characterised by dry, scaly skin caused by abnormal proliferation of epidermal keratinocytes. The use of in vitro disease models has become an increasingly popular method to study PS and AD due to the high reproducibility and accuracy in recapitulating the pathogenesis of these conditions. However, due to the extensive range of in vitro models available and the majority of these being at early stages of production, areas of development are needed. This review summarises the key features of PS and AD, the different types of in vitro models available to study their pathophysiology and evaluating their efficacy in addition to discussing future research opportunities.

Keywords: 3D models; atopic dermatitis (AD); fibroblast; in vitro; keratinocyte; psoriais.

Publication types

Review