Plasmacytoid dendritic cells: Welcome back to the DC fold

Gary Reynolds; Alice Tirard; Alexandra-Chloé Villani

doi:10.1016/j.immuni.2022.02.011

Plasmacytoid dendritic cells: Welcome back to the DC fold

Immunity. 2022 Mar 8;55(3):380-382. doi: 10.1016/j.immuni.2022.02.011.

Authors

Gary Reynolds¹, Alice Tirard², Alexandra-Chloé Villani³

Affiliations

¹ Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, NE2 4HH, UK; Center for Immunology and Inflammatory Diseases, Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA.
² Center for Immunology and Inflammatory Diseases, Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA.
³ Center for Immunology and Inflammatory Diseases, Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Boston, MA 02129, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: avillani@mgh.harvard.edu.

PMID: 35263562
DOI: 10.1016/j.immuni.2022.02.011

Abstract

The presumed common origin of plasmacytoid and conventional dendritic cells has been the contentious subject of recent debate. In this issue of Immunity, Feng et al. employed an inducible cell barcoding system to track clonal relationships and uncovered a surprising close developmental relationship between cDC1s and pDCs.

Publication types

Comment

MeSH terms

Cells, Cultured
Dendritic Cells* / immunology