Palladium-Catalyzed Silylacylation of Allenes Using Acylsilanes

Tetsuya Inagaki; Shun Sakurai; Masahiro Yamanaka; Mamoru Tobisu

doi:10.1002/anie.202202387

Palladium-Catalyzed Silylacylation of Allenes Using Acylsilanes

Angew Chem Int Ed Engl. 2022 May 16;61(21):e202202387. doi: 10.1002/anie.202202387. Epub 2022 Mar 23.

Authors

Tetsuya Inagaki¹, Shun Sakurai¹, Masahiro Yamanaka², Mamoru Tobisu^{1

3}

Affiliations

¹ Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, 565-0871, Japan.
² Department of Chemistry and Research Center for Smart Molecules, Faculty of Science, Rikkyo University, Nishi-Ikebukuro, Toshima-ku, Tokyo, 171-8501, Japan.
³ Innovative Catalysis Science Division, Institute for Open and Transdisciplinary Research Initiatives (ICS-OTRI), Osaka University, Suita, Osaka, 565-0871, Japan.

PMID: 35263006
DOI: 10.1002/anie.202202387

Abstract

We have developed a palladium-catalyzed addition of a C-Si bond of acylsilanes across a range of unactivated allenes. The reaction proceeds with complete regioselectivity, in which a silyl group binds to the central carbon of the allene, allowing for the straightforward access to functionalized alkenylsilane derivatives.

Keywords: C−Si Bond Activation; Insertion; Organosilicon Compounds; Pd Catalysis; Silylation.

Abstract

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