Characterization of fetal exposure to multiple metals among an urban population: A case study of New York City

Brian Pavilonis; Andrew Maroko; Bo Cai; Jin Shin; Nadine Lahage; Arpit Gupta; Marcy Stein-Albert; Uday Patil; Tom Elena Dubov; Hoda Karbalivand; Suzanne McDermott

doi:10.1016/j.envres.2022.113050

Characterization of fetal exposure to multiple metals among an urban population: A case study of New York City

Environ Res. 2022 Aug:211:113050. doi: 10.1016/j.envres.2022.113050. Epub 2022 Mar 5.

Authors

Affiliations

¹ City University of New York Graduate School of Public Health and Health Policy, 55 W. 125th Street, New York, NY, 10027, USA. Electronic address: brian.pavilonis@sph.cuny.edu.
² City University of New York Graduate School of Public Health and Health Policy, 55 W. 125th Street, New York, NY, 10027, USA.
³ University of South Carolina, Columbia, SC, USA.
⁴ Medgar Evers College of The City University of New York, 1650 Bedford Avenue, Brooklyn, NY, 11225, USA.
⁵ New York City Health and Hospitals, New York City, NY, USA.

PMID: 35259408
DOI: 10.1016/j.envres.2022.113050

Abstract

Introduction: Metals and metalloids are ubiquitous and persistent in urban areas and are generally released into the environment as mixtures.

Objectives: The purpose of this study was to establish baseline concentrations of selected elements in meconium samples among a large urban population in the US and understand the spatial variability in concentrations. The association of metal mixtures on birth weight was also assessed.

Methods: This cross-sectional study was conducted across five public hospitals located in New York City, NY (NYC) in four boroughs. We collected meconium sample from 116 infants during the first 24 h after delivery and quantified 11 metals using ICP-MS. Principal component analysis was used to determine metal mixtures and their association with birth weight. Spatial hot spots of each metal were calculated using the Getis-Ord (GI*).

Results: Essential elements were detected in all samples with Zn in the greatest abundance (median = 274.5 μg/g) and Mo in the least (median = 0.1845 μg/g). Pb was detected in all but two samples (median = 0.0222 μg/g), while Cd levels were detected in approximately half of the samples (median = 0.0019 μg/g). Co-located hot spots were detected for Cu, Zn, and Fe in southeast Brooklyn; Cd, Cr, and Ni in eastern Queens; and Al and Mo in south Queens. There was a significant inverse relationship between Pb concentrations (beta = -1935.7; p = 0.006) and the mixture of Cr, Cu, Mo, Zn (beta = -157.7; p = 0.045) and birth weight.

Conclusions: Our findings indicate that meconium is an effective biomarker for measuring metal exposures among an urban population. We were able to quantify detectable levels of ten of the eleven metals measured in the study and characterize nutritionally necessary trace elements and metals derived from anthropogenic sources without biologic need in a cohort of NYC newborns. Further research needs to establish the change point from necessary to toxic, for the essential elements.

Keywords: Fetal exposure; Meconium; Metal contamination; Metal exposure; Urban exposure.

MeSH terms

Birth Weight
Cadmium* / analysis
Cross-Sectional Studies
Environmental Monitoring
Humans
Infant
Infant, Newborn
Lead / analysis
Metals, Heavy* / analysis
New York City
Urban Population

Substances

Metals, Heavy
Cadmium
Lead