The Relationship between Hepatic High FIB-4 Score and COVID-19 Pneumonia

Clin Lab. 2022 Mar 1;68(3). doi: 10.7754/Clin.Lab.2021.210616.

Abstract

Background: We aimed to compare the level of hepatic FIB-4 scores between COVID-19 patients who had pneumonia and COVID-19 patients who had no pneumonia in an attempt to develop a risk assessment after the treatment and recovery of active COVID-19 infection.

Methods: The study included 80 patients who were consecutively selected and admitted to an internal medicine outpatient clinic for a control examination after COVID-19 infection. Chest tomography was performed on all patients during the COVID-19 infection. Patients were divided into two groups as those with and without lung involvement on CT. COVID-19 infection was diagnosed using real-time reverse transcription-polymerase chain reaction (RT-PCR). The hepatic fibrosis 4 (FIB-4) index score was calculated for each patient. The statistical analyses were performed using Student's t-test and chi-squared tests.

Results: We found that the increased hepatic FIB-4 index score in patients with pneumonia group was statistically significant compared to the control group (p < 0.001). The regression analysis showed that the hepatic FIB-4 index has significant prognostic efficiencies in both uni- and multivariate models (p < 0.05).

Conclusions: The hepatic FIB-4 index appears to be a simple parameter with a good prognostic value in patients with COVID-19 infection.

MeSH terms

  • COVID-19* / diagnosis
  • Humans
  • Prognosis
  • Real-Time Polymerase Chain Reaction
  • Retrospective Studies
  • SARS-CoV-2
  • Tomography, X-Ray Computed / methods