Synthesis of phosphatidic acids via cobalt(salen) catalyzed epoxide ring-opening with dibenzyl phosphate

Ruben L H Andringa; Marijn Jonker; Adriaan J Minnaard

doi:10.1039/d2ob00168c

Synthesis of phosphatidic acids via cobalt(salen) catalyzed epoxide ring-opening with dibenzyl phosphate

Org Biomol Chem. 2022 Mar 16;20(11):2200-2204. doi: 10.1039/d2ob00168c.

Authors

Ruben L H Andringa¹, Marijn Jonker¹, Adriaan J Minnaard¹

Affiliation

¹ Stratingh Institute for Chemistry, University of Groningen Nijenborgh 7, 9747AG, Groningen, The Netherlands. a.j.minnaard@rug.nl.

Abstract

With a CoIII(salen)OTs catalyst, dibenzyl phosphate ring-opens a variety of terminal epoxides with excellent regio-selectively and yields up to 85%. The reaction is used in a highly efficient synthesis of enantiopure mixed-diacyl phosphatidic acids, including a photoswitchable phosphatidic acid mimic.

Publication types

Research Support, Non-U.S. Gov't