Capgras Syndrome as the Core Manifestation of Early-Onset Alzheimer's Disease

J Alzheimers Dis. 2022;87(1):155-160. doi: 10.3233/JAD-215565.

Abstract

Capgras syndrome (CS) was usually considered a symptom of a functional disorder in the young, most commonly schizophrenia, or an organic disorder in the elderly. The occurrence of CS among early-onset Alzheimer's disease (EOAD) is extremely rare. We describe a case in which the unrecognition of CS as part of EOAD resulted in a wrong psychiatric diagnosis and inappropriate treatment. This paper aims to acknowledge CS as an early or core manifestation and highlight EOAD as a differential diagnosis of mental disorders in young people, even without a remarkable family history.

Keywords: Alzheimer’s disease; biomarkers; capgras syndrome; early-onset dementia; mental disorders.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Aged
  • Alzheimer Disease* / psychology
  • Capgras Syndrome* / diagnosis
  • Capgras Syndrome* / etiology
  • Diagnosis, Differential
  • Humans
  • Schizophrenia*