Transformed Mycosis Fungoides with a Cytotoxic T-Cell Phenotype

Int J Surg Pathol. 2022 Oct;30(7):816-822. doi: 10.1177/10668969221084267. Epub 2022 Mar 7.

Abstract

Mycosis fungoides (MF) is a cutaneous T-cell lymphoma and occasionally undergo large cell transformation (transformed MF, TMF), resulting in a poorer clinical outcome. We describe a case of TMF with an immunophenotypic shift. MF showed the CD4 + CD8- T-cell phenotype, while TMF exhibited the CD4-CD8 + T-cell phenotype. Moreover, TMF expressed cytotoxic markers of TIA1 and Granzyme B. A PCR analysis of T-cell receptor genes revealed peak sizes that were the same in both biopsies, indicating that these two lymphomas were derived from the same clone.

Keywords: CD8-positive; TCR; cytotoxic; mycosis fungoides; transformation.

Publication types

  • Case Reports

MeSH terms

  • Cell Transformation, Neoplastic / genetics
  • Humans
  • Lymphoma, T-Cell, Cutaneous* / diagnosis
  • Lymphoma, T-Cell, Cutaneous* / genetics
  • Lymphoma, T-Cell, Cutaneous* / pathology
  • Mycosis Fungoides* / diagnosis
  • Mycosis Fungoides* / genetics
  • Mycosis Fungoides* / pathology
  • Phenotype
  • Skin Neoplasms* / diagnosis
  • Skin Neoplasms* / genetics
  • Skin Neoplasms* / pathology
  • T-Lymphocytes / pathology