The development of bioactive polymer nanofiber sheets based on eco-friendly components is required to meet the needs of various medical applications as well as to preserve the environment. This study aimed to fabricate biohybrid nanofibers based on water-soluble polymers and aqueous extract of myrrh. The myrrh extract was incorporated into poly(vinyl alcohol)/tragacanth gum nanofiber mats (myrrh@PVA/TG) by the green electrospinning technique. Various characteristics of the prepared fibers such as morphology, fiber diameter distribution, crystallinity, and thermal stability were studied. The results confirmed that the morphology of biohybrid nanofibers was uniform without beads and tragacanth gum plays an important role in controlling the average diameter of fibers and the crystallinity. The antibacterial properties of the developed biohybrid nanofibers were investigated against common pathogens of Gram-positive and Gram-negative bacteria by the standard disc diffusion method. A significant antibacterial activity was observed toward bacterial strains after incorporation of aqueous myrrh extract into nanofibers, which increased on increasing the extract ratio. Due to their eco-friendly components and significant antibacterial activity, the prepared biohybrid nanofibers will open new avenues toward incorporating aqueous herbal extracts into degradable polymer fibers for use in many antibacterial applications.
© 2022 The Authors. Published by American Chemical Society.