Data for characterisation of nanoformulations formed by cationic 1,4-dihydopyridine and calix[4]arene compositions

Martins Rucins; Roman Rodik; Aiva Plotniece; Nadiia Pikun; Mara Plotniece; Arkadij Sobolev; Vitaly Kalchenko; Karlis Pajuste

doi:10.1016/j.dib.2022.107988

Data for characterisation of nanoformulations formed by cationic 1,4-dihydopyridine and calix[4]arene compositions

Data Brief. 2022 Feb 23:41:107988. doi: 10.1016/j.dib.2022.107988. eCollection 2022 Apr.

Authors

Martins Rucins¹, Roman Rodik², Aiva Plotniece¹, Nadiia Pikun¹, Mara Plotniece³, Arkadij Sobolev¹, Vitaly Kalchenko², Karlis Pajuste¹

Affiliations

¹ Latvian Institute of Organic Synthesis, Aizkraukles str. 21, Riga LV-1006, Latvia.
² Institute of Organic Chemistry, National Academy of Science of Ukraine, Murmanska str. 5, Kiev 02660, Ukraine.
³ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Riga Stradiņš University, Dzirciema str. 16, Riga LV-1007, Latvia.

Abstract

In this data file the characterisation of nanoformulations obtained from calix[4]arene/1,4-dihydropyridine (1,4-DHP) compositions in the various component ratio in an aqueous medium was performed by dynamic light scattering (DLS) technique. The hydrodynamic diameters of nanoparticle main population, polydispersity index and stability of nanoformulation were determined. In this article provided data are directly related to the previously published research articles - "Gene delivery agents possessing antiradical activity: Self-assembling cationic amphiphilic 1,4-dihydropyridine derivatives" [1], and "Studies of the physicochemical and structural properties of self-assembling cationic pyridine derivatives as gene delivery agents" [2] where was described synthesis, transfection activity of 1,1'-((3,5-bis((dodecyloxy)carbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl)bis(methylene))bis(pyridin-1-ium) dibromide presented in this data file; and with articles "Cationic amphiphilic calixarenes to compact DNA into small nanoparticles for gene delivery" [3] and "Self-aggregation in aqueous solution of amphiphilic cationic calix[4]arenes. Potential use as vectors and nanocarriers" [4] where was described synthesis and ability to condense DNA for also mentioned calix[4]arenes - 5,11,17,23-tetra-(3-methylimidazolium)-methylene-25,26,27,28-etradodecyloxycalix[4]arene tetrachloride, 5,11,17,23-tetra(N,N-dimethyl-N-hydroxyethylammonium)-methylene-25,26,27,28-tetradodecyloxycalix[4]arene tetrachloride and 5,11,17,23-tetra(N,N-dimethyl-N-hydroxyethylammonium)-methylene-25,26,27,28-tetrahexadecyloxycalix[4]arene tetrachloride. Information provided in this data file can be used in medicinal chemistry for development of novel synthetic lipid nanoformulations.

Keywords: 1,4-dihydropyridine; Calix[4]arene; DLS; Nanoparticles; Synthetic lipids.