Clinical Nomogram for Predicting the Prognosis of Patients With Pulmonary Venous Obstruction After Total Anomalous Pulmonary Venous Connection Repair

Ling Chen; Zhihuang Qiu; Fan Xu; Xingfeng Chen; Liangwan Chen

doi:10.3389/fcvm.2022.733253

Clinical Nomogram for Predicting the Prognosis of Patients With Pulmonary Venous Obstruction After Total Anomalous Pulmonary Venous Connection Repair

Front Cardiovasc Med. 2022 Feb 16:9:733253. doi: 10.3389/fcvm.2022.733253. eCollection 2022.

Authors

Ling Chen^{1

2

3}, Zhihuang Qiu^{1

2

3}, Fan Xu^{1

2

3}, Xingfeng Chen¹, Liangwan Chen^{1

2

3}

Affiliations

¹ Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
² Fujian Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, China.
³ Fujian Provincial Special Reserve Talents Laboratory, Fujian Province University, Fuzhou, China.

Abstract

Background: The aim of this study was to establish a nomogram to quantify the risk of postoperative pulmonary venous obstruction (PVO) and to make a scientific decision through the decision curve.

Methods: In total, 151 PVO patients with total anomalous pulmonary venous connection (TAPVC) repair in our hospital from December 2008 to December 2015 were involved in this study. A nomogram was generated based on the contribution weights of variables, which were found out by logistic analysis. The optimal clinical decision point was determined by the decision analysis and clinical impact curve, which could assess the net benefit between the nomogram and each independent risk factor for postoperative PVO.

Result: Pulmonary venous obstruction with TAPVC repair was found to be positively and independently correlated with preoperative pulmonary hypertension, surgical methods, and preoperative pulmonary venous stenosis.

Conclusions: The study introduced a novel model to aid in clinical decisions making for the patients with TAPVC individually, which may shed light on the evaluation of PVO risk.

Keywords: decision-making curve; nomogram; postoperative pulmonary venous obstruction; preoperative pulmonary venous stenosis; total anomalous pulmonary venous connection.