Molecular Mechanism Underlying the Regulatory Effect of Vine Tea on Metabolic Syndrome by Targeting Redox Balance and Gut Microbiota

Xixin Zhou; Ying Song; Chaoxi Zeng; Haowei Zhang; Chenghao Lv; Meng Shi; Si Qin

doi:10.3389/fnut.2022.802015

Molecular Mechanism Underlying the Regulatory Effect of Vine Tea on Metabolic Syndrome by Targeting Redox Balance and Gut Microbiota

Front Nutr. 2022 Feb 17:9:802015. doi: 10.3389/fnut.2022.802015. eCollection 2022.

Authors

Xixin Zhou¹, Ying Song¹, Chaoxi Zeng², Haowei Zhang², Chenghao Lv^{1

2}, Meng Shi², Si Qin^{1

2}

Affiliations

¹ Department of Biological Sciences, College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China.
² Lab of Food Function and Nutrigenomics, College of Food Science and Technology, Hunan Agricultural University, Changsha, China.

Abstract

Metabolic syndrome (MS) is a metabolic disorder that arises from the increasing prevalence of obesity. The pathophysiology seems to be largely attributable to the imbalance of lipid and glucose metabolism, redox signaling pathways, and gut microbiota. The increased syndromes, such as type 2 diabetes and cardiovascular disease demands natural therapeutic attention for those at high risk. Vine tea, as a traditional medicinal and edible resource rich in flavonoids, especially for dihydromyricetin (DHM), exhibits promising health benefits on the intervention of MS, but the specific molecular mechanism has not been systematically elucidated. The present article aims to summarize the regulatory effects and biological targets of vine tea or DHM on MS, and analyze the underlying potential molecular mechanisms in cells, animals, and humans, mainly by regulating the redox associated signaling pathways, such as Nrf2, NF-κB, PI3K/IRS2/AKT, AMPK-PGC1α-SIRT1, SIRT3 pathways, and the crosstalk among them, and by targeting several key biomarkers. Moreover, vine tea extract or DHM has a positive impact on the modulation of intestinal microecology by upregulating the ratio of Firmicutes/Bacteroidetes (F/B) and increasing the relative abundance of Akkermansia muciniphila. Therefore, this review updated the latest important theoretical basis and molecular evidence for the development and application of vine tea in dietary functional products or drugs against MS and also imputed the future perspectives to clarify the deep mechanism among vine tea or DHM, redox associated signaling pathways, and gut microbiota.

Keywords: biotransformation; dihydromyricetin; gut microbiota; metabolic syndrome; redox signaling pathway.

Publication types

Review