A Case Report of a 3-Year-Old Child With Anaphylactic Shock After a Diclofenac Suppository Confirmed by Serial Tryptase and a Basophil Activation Test

Wun-Yan Huang; Tsu-Man Chiu; Su-Feng Kuo; Wen-Hung Chung; Yi-Giien Tsai

doi:10.3389/fped.2021.802715

A Case Report of a 3-Year-Old Child With Anaphylactic Shock After a Diclofenac Suppository Confirmed by Serial Tryptase and a Basophil Activation Test

Front Pediatr. 2022 Feb 17:9:802715. doi: 10.3389/fped.2021.802715. eCollection 2021.

Authors

Wun-Yan Huang^{1

2}, Tsu-Man Chiu^{3

4}, Su-Feng Kuo⁵, Wen-Hung Chung⁶, Yi-Giien Tsai^{7

8

9}

Affiliations

¹ Department of Pediatric Emergency Medicine, Children Hospital, China Medical University, Taichung, Taiwan.
² Department of Medicine, School of Medicine, China Medical University, Taichung, Taiwan.
³ Department of Dermatology, Changhua Christian Hospital, Changhua City, Taiwan.
⁴ Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
⁵ Department of Laboratory Medicine, Changhua Christian Hospital, Changhua City, Taiwan.
⁶ Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei and Linkou Branch, College of Medicine, Chang Gung University, Taipei, Taiwan.
⁷ Departments of Pediatrics, Changhua Christian Children's Hospital, Changhua City, Taiwan.
⁸ School of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.
⁹ School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Abstract

Diclofenac is one of the most commonly used non-steroidal anti-inflammatory drug (NSAID) agents for fever management by general practitioners. Anaphylaxis due to suppository of diclofenac sodium (Voltaren) is extremely rare in children. We report the case of a 3-year-old girl with anaphylactic shock after a diclofenac suppository with confirmation by serial tryptase and a basophil activation test.

Keywords: anaphylaxis; basophil activation test; diclofenac; non-steroidal anti-inflammatory drug; tryptase.

Publication types

Case Reports