Antioxidant and Antiaging Properties of Agar Obtained from Brown Seaweed Laminaria digitata (Hudson) in D-Galactose-Induced Swiss Albino Mice

B S Reshma; Thabitha Aavula; Vignesh Narasimman; Saravanan Ramachandran; Musthafa Mohamed Essa; M Walid Qoronfleh

doi:10.1155/2022/7736378

Antioxidant and Antiaging Properties of Agar Obtained from Brown Seaweed Laminaria digitata (Hudson) in D-Galactose-Induced Swiss Albino Mice

Evid Based Complement Alternat Med. 2022 Feb 24:2022:7736378. doi: 10.1155/2022/7736378. eCollection 2022.

Authors

B S Reshma¹, Thabitha Aavula¹, Vignesh Narasimman¹, Saravanan Ramachandran¹, Musthafa Mohamed Essa², M Walid Qoronfleh³

Affiliations

¹ Native Medicine and Marine Pharmacology Laboratory, Department of Medical Biotechnology, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, TN 603 103, India.
² Department of Food Science and Nutrition, CAMS, Sultan Qaboos University, Muscat, Oman.
³ Q3CG Research Institute (QRI), Research & Policy Division, 7227 Rachel Drive, Ypsilanti, MI 48917, USA.

Abstract

The present paper explores the antioxidant and antiaging properties of agar extracted from Laminaria digitata (L. digitata) on a D-galactose (D-Gal)-induced mouse model. Experimental mice were divided into four groups: group I comprised of control nontreated mice, group II comprised of D-Gal-induced mice, group III mice were treated with extracted agar after D-Gal induction, and group IV mice were given ascorbic acid as a positive control. Antioxidant enzymes and aging marker proteins declined significantly in group II, whereas they were normal in group III and group IV mice. Expressions of interleukin-1β (IL-1β) in D-Gal-induced mice were significantly enhanced in the liver and brain of the experimental mice, which were otherwise normal in agar-treated mice. Also, IL-6 levels were significantly increased in the liver and reversed in the brain of D-gal mice, while it was regularly in the agar-treated mice. The histopathological analysis of D-Gal-induced mice showed spongiosis and tangles in brain cells, increased fat and decreased collagen contents in the skin, and few dilated sinuses in the hepatic cells. The changes were under control in group III and group IV mice, suggesting the protective effects of agar extracted from L. digitata and ascorbic acid.