Background: Colorectal polyp is a common disease of the gastrointestinal tract, which is closely related to colorectal cancer. Diabetes mellitus (DM) is a major public health disease that seriously threatens human health. This study aimed to investigate the risk factors of colorectal polyps and its relationship with type 2 DM (T2DM).
Methods: A total of 352 patients with colorectal polyps (diagnosed by colonoscopy) in our hospital from June 2018 to June 2020 were enrolled as the observation group, and 201 healthy people with normal colonoscopy results were selected as the control group. The levels of blood lipids, blood glucose, liver function, serum uric acid (UA), and glycosylated hemoglobin (HbA1c) were compared between the two groups. Univariate and multiple logistic regression analyses were performed to analyze the risk factors related to colorectal polyps.
Results: Compared to the control group, the levels of HbA1c, fasting plasma glucose (FPG), 2-hour post-meal blood glucose (2hPG), total cholesterol (TC), and serum UA in the observation group were significantly higher (P<0.05). Univariate analysis showed that the incidence of colorectal polyps was significantly correlated with gender, smoking, age, non-alcoholic fatty liver disease (NAFLD), and type 2 diabetes mellitus (T2DM) (P<0.05). Multiple Logistic regression analysis showed that gender (male), age (≥60 years), and T2DM were independent risk factors for colorectal polyps (P<0.05).
Conclusions: Abnormal metabolic indices may be closely related to the development of colorectal polyps. Gender (male), age (≥60 years), smoking, NAFLD, T2DM, as well as increased blood glucose, UA, and TC were identified as the risk factors for colorectal polyps.
Keywords: Colorectal polyps; blood glucose; non-alcoholic fatty liver disease (NAFLD); risk factor; type 2 diabetes mellitus (T2DM).