Role of fruits in aging and age-related disorders

Exp Gerontol. 2022 Jun 1:162:111763. doi: 10.1016/j.exger.2022.111763. Epub 2022 Mar 3.

Abstract

Aging is a collection of changes that contribute to decline in maximum function and ultimately death of an organism. This process is controlled and initiated by several mechanisms including telomere shortening, oxidative stress, AMP-activated protein kinase and sirt-1. Several therapies have been reported to relieve the process of aging. Among these, diet therapy seems to be the most appropriate approach. Fruits are an important part of regular diet. They contain several compounds which have potential to handle the problem of aging and its related disorders. The present paper provides a comprehensive review on different factors present in various fruits related to the process of aging together with their antiaging mechanisms.

Keywords: AMPK; Aging; Oxidative stress; Reactive oxygen spices; Sirt 1; Telomere.

Publication types

  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism
  • Aging* / metabolism
  • Aging* / physiology
  • Fruit*
  • Oxidative Stress / physiology
  • Sirtuin 1 / metabolism
  • Telomere
  • Telomere Shortening* / physiology

Substances

  • AMP-Activated Protein Kinases
  • Sirtuin 1