Recent progress of collagen, chitosan, alginate and other hydrogels in skin repair and wound dressing applications

Int J Biol Macromol. 2022 May 31:208:400-408. doi: 10.1016/j.ijbiomac.2022.03.002. Epub 2022 Mar 3.

Abstract

Human understanding of skin is constantly ongoing. Great progress has been made in skin repair, wound dressing regeneration biomaterials research in recent years. This review introduced the clinical research and guiding principles of skin repair, wound dressing biomaterials at home and abroad, introduced the classification of various skin repair and wound dressing, listed the composition and performance of different dressing biomaterials, including traditional, natural, synthetic, tissue-engineered dressing materials were extensively reviewed. The biological molecular structures and biological function characteristics of different dressing biomaterials are comprehensively reviewed. Collagen, chitosan, alginate hydrogels et al. as the most popular biological macromolecules in skin repair and wound dressing applications were reviewed. The future development direction is also prospected. This paper reviews the research progress of advanced functional skin repair and wound dressing, which provides a reference for the modifications and applications of wound dressings.

Keywords: Chitosan; Collagen; Wound dressings.

Publication types

  • Review

MeSH terms

  • Alginates / chemistry
  • Bandages
  • Biocompatible Materials / pharmacology
  • Chitosan* / chemistry
  • Collagen
  • Humans
  • Hydrogels / chemistry
  • Hydrogels / therapeutic use
  • Skin
  • Wound Healing

Substances

  • Alginates
  • Biocompatible Materials
  • Hydrogels
  • Collagen
  • Chitosan