Two new triterpene glycosides with antiproliferative activities on HepG2 from Phytolacca acinosa fruit fermentation broth

Biao Li; Yuxing Wang; Changfu Wang; Donghui Peng; Huilin Su; Congjing Shi; Wenlong Liu; Haixue Kuang; Qiuhong Wang

doi:10.1080/14786419.2022.2042284

Two new triterpene glycosides with antiproliferative activities on HepG2 from Phytolacca acinosa fruit fermentation broth

Nat Prod Res. 2023 Jul;37(14):2327-2334. doi: 10.1080/14786419.2022.2042284. Epub 2022 Mar 4.

Authors

Biao Li^{1

2}, Yuxing Wang^{1

2}, Changfu Wang^{1

2}, Donghui Peng^{1

3}, Huilin Su^{1

2}, Congjing Shi^{1

2}, Wenlong Liu⁴, Haixue Kuang³, Qiuhong Wang^{1

2}

Affiliations

¹ Guangdong Standardized Processing Engineering Technology Research Center of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
² Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.
³ College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China.
⁴ Hunan Wenlong Pharmaceutical Co. LTD, Hengyang, China.

PMID: 35245978
DOI: 10.1080/14786419.2022.2042284

Abstract

Two new oleanane-type triterpene glycosides, phytolasides A (1) and B (2), and six known ones (3-8), were isolated from Phytolacca acinosa fruit fermentation broth. Their structures were elucidated by HR-ESI-MS and 1 D- and 2 D-NMR spectroscopic methods. Antiproliferation of compounds 1 and 2 against HepG2 cells was examined by using CCK8 assays.

Keywords: Antiproliferation; Phytolacca acinosa; fruit fermentation broth; triterpene glycosides.

MeSH terms

Fermentation
Fruit
Glycosides / chemistry
Glycosides / pharmacology
Molecular Structure
Phytolacca* / chemistry
Triterpenes* / chemistry
Triterpenes* / pharmacology

Substances

Glycosides
Triterpenes