Quo vadis, neutrophil?

Rodrigo J Gonzalez; Ulrich H von Andrian

doi:10.1016/j.cell.2022.02.009

Quo vadis, neutrophil?

Cell. 2022 Mar 3;185(5):759-761. doi: 10.1016/j.cell.2022.02.009.

Authors

Rodrigo J Gonzalez¹, Ulrich H von Andrian²

Affiliations

¹ Department of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
² Department of Immunology, Harvard Medical School, Boston, MA, USA; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. Electronic address: uva@hms.harvard.edu.

PMID: 35245478
DOI: 10.1016/j.cell.2022.02.009

Abstract

Neutrophil recruitment from blood into tissues is a hallmark of inflammation and anti-microbial host defense. In this issue, De Giovanni et al. describe an unanticipated role for a serotonin metabolite, 5-HIAA, which is produced by activated platelets and mast cells and engages the orphan receptor, GPR35, to recruit neutrophils to inflamed tissues.

Publication types

Comment

MeSH terms

Blood Platelets* / metabolism
Humans
Inflammation / metabolism
Mast Cells / metabolism
Neutrophil Infiltration
Neutrophils* / metabolism