Releasing the trap: How the segregase p97 extracts PARP1 from chromatin

Maximilian J Götz; Julian Stingele

doi:10.1016/j.molcel.2022.02.012

Releasing the trap: How the segregase p97 extracts PARP1 from chromatin

Mol Cell. 2022 Mar 3;82(5):889-890. doi: 10.1016/j.molcel.2022.02.012.

Authors

Maximilian J Götz¹, Julian Stingele²

Affiliations

¹ Department of Biochemistry, Ludwig-Maximilians-University, 81377 Munich, Germany; Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany.
² Department of Biochemistry, Ludwig-Maximilians-University, 81377 Munich, Germany; Gene Center, Ludwig-Maximilians-University, 81377 Munich, Germany. Electronic address: stingele@genzentrum.lmu.de.

PMID: 35245455
DOI: 10.1016/j.molcel.2022.02.012

Abstract

Krastev et al. (2022) identify a cellular mechanism that counteracts cytotoxic trapping of PARP1 induced by clinical PARP inhibitors. SUMO-targeted ubiquitylation of trapped PARP1 is shown to trigger the enzymes' extraction from chromatin by the p97 ATPase.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chromatin* / genetics
Plant Extracts
Poly (ADP-Ribose) Polymerase-1 / metabolism
Poly(ADP-ribose) Polymerase Inhibitors* / pharmacology
Ubiquitination / drug effects

Substances

Chromatin
Plant Extracts
Poly(ADP-ribose) Polymerase Inhibitors
Poly (ADP-Ribose) Polymerase-1