Part 1: Imaging findings of common immune checkpoint inhibitor-related adverse effects

J Med Imaging Radiat Oncol. 2022 Jun;66(4):495-501. doi: 10.1111/1754-9485.13396. Epub 2022 Mar 4.

Abstract

Over the last decade or so, immunotherapy and in particular immune checkpoint inhibitors have become common in the treatment of numerous cancers and have revolutionised oncology. The unique mechanisms of these agents has resulted in novel tumour response patterns and also new drug-related toxicities, both of which can have specific findings on imaging. The widespread and increasing use of these agents means these findings are now encountered across many radiology practices beyond just specialist oncology units. This pictorial essay aims to describe and illustrate imaging findings associated with common and important immune-related adverse events as a result of treatment with immune checkpoint inhibitors.

Keywords: autoimmunity; drug-related side effects and adverse reactions; immune checkpoint inhibitors; immunotherapy; medical oncology.

MeSH terms

  • Drug-Related Side Effects and Adverse Reactions*
  • Humans
  • Immune Checkpoint Inhibitors
  • Immunotherapy / adverse effects
  • Medical Oncology
  • Neoplasms* / diagnostic imaging
  • Neoplasms* / drug therapy

Substances

  • Immune Checkpoint Inhibitors