The mechanism of methamphetamine toxicity and addiction is the key research direction of forensic toxicology, and the development of omics technology provides a new platform for further study of this direction. METH toxic damage and addiction are reflected differently in genes, ribonucleic acid (RNA) transcription, protein and metabolism. This article summarizes the achievements and shortcomings of multi-omics technologies such as genome, transcriptome, metabolome and proteome in the study of METH damage and addiction, and discusses the strategies and advantages of multi-omics combined analysis in the study of METH toxic damage and addiction mechanism, in order to provide more useful reference information for forensic toxicology of METH.
甲基苯丙胺（methamphetamine，METH）的毒性损伤和成瘾机制是法医毒理学关注的重点，而组学技术的发展为此类研究提供了新的平台。METH毒性损伤和成瘾在基因、核糖核酸（ribonucleic acid，RNA）转录、蛋白和代谢水平均有不同的体现。本文拟从基因组、转录组、代谢组、蛋白质组等多组学技术出发，总结其在METH损伤和成瘾相关研究中的成果与不足，并对多组学联合分析在METH毒性损伤和成瘾机制研究中的策略和优势进行论述，从而为METH的法医毒理学鉴定提供更多参考信息。.
Keywords: addiction; forensic toxicology; genomics; metabolomics; methamphetamine; proteomics; review; toxic effect; transcriptomics.