Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

Yan Chen; Guisheng Wang; Yilin Yuan; Ge Zou; Wencong Yang; Qi Tan; Wenyi Kang; Zhigang She

doi:10.3389/fchem.2022.842405

Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

Front Chem. 2022 Feb 15:10:842405. doi: 10.3389/fchem.2022.842405. eCollection 2022.

Authors

Yan Chen^{1

2}, Guisheng Wang¹, Yilin Yuan¹, Ge Zou², Wencong Yang², Qi Tan², Wenyi Kang¹, Zhigang She²

Affiliations

¹ National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng, China.
² School of Chemistry, Sun Yat-sen University, Guangzhou, China.

Abstract

Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A-C (11-13), as well as five known analogues 3, 4, 6-8 and 14 were isolated from mangrove endophytic fungus Fusarium sp. 2ST2. Their structures and absolute configurations were established by spectroscopic analysis, density functional theory-gauge invariant atomic orbital NMR calculation with DP4+ statistical analysis, and electronic circular dichroism calculation. Compounds 1 and 2 showed significant cytotoxicity against human A549 cell lines with IC₅₀ values of 8.7 and 4.3 μM, respectively.

Keywords: Fusarium sp.; benzofuran; chromone; cytotoxicity; endophytic fungus; mangrove.