Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632

Rima Koike; Yoshihiro Watanabe; Kazuho Kato; Yudai Mikasa; Kota Shimizu; Kenichi Nonaka; Masako Honsho; Takuya Suga; Rei Hokari; Aki Ishiyama; Yukihiro Asami; Masato Iwatsuki

doi:10.1038/s41429-022-00512-y

Shikinefragalides A-D, new tricyclic macrolides produced by Stachybotryaceae sp. FKI-9632

J Antibiot (Tokyo). 2022 Apr;75(4):199-206. doi: 10.1038/s41429-022-00512-y. Epub 2022 Mar 4.

Authors

Rima Koike^#¹, Yoshihiro Watanabe^#^{1

2}, Kazuho Kato³, Yudai Mikasa³, Kota Shimizu³, Kenichi Nonaka^{1

2}, Masako Honsho², Takuya Suga^{1

2}, Rei Hokari^{1

2}, Aki Ishiyama^{1

2}, Yukihiro Asami^{1

2}, Masato Iwatsuki^{4

5}

Affiliations

¹ Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Tokyo, Japan.
² Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Tokyo, Japan.
³ School of Science, Kitasato University, 1-15-1, Kitazato, Minami-ku, Sagamihara, Kanagawa, 252-0373, Japan.
⁴ Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Tokyo, Japan. iwatuki@lisci.kitasato-u.ac.jp.
⁵ Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Tokyo, Japan. iwatuki@lisci.kitasato-u.ac.jp.

^# Contributed equally.

Abstract

Four new tricyclic macrolides, named shikinefragalides A (1), B (2), C (3) and D (4), were isolated by physicochemical (PC) screening from a static culture material of Stachybotryaceae sp. FKI-9632. Their structures were elucidated as new analogs of colletofragarones by MS and NMR analyses. Compounds 1 and 2 showed weak antimalarial activity and cytotoxicity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents
Antimalarials* / pharmacology
Hypocreales* / chemistry
Macrolides / chemistry
Macrolides / pharmacology
Magnetic Resonance Spectroscopy

Substances

Anti-Bacterial Agents
Antimalarials
Macrolides