Synthesis, characterization and antimicrobial properties of two derivatives of pyrrolidine-2,5-dione fused at positions-3,4 to a dibenzobarrelene backbone

Emmanuel Sopbué Fondjo; Abdou Salamou Njoya; Jean-de-Dieu Tamokou; Giscard Doungmo; Bruno Ndjakou Lenta; Peter F W Simon; Apollinaire Tsopmo; Jules-Roger Kuiate

doi:10.1186/s13065-022-00801-5

Synthesis, characterization and antimicrobial properties of two derivatives of pyrrolidine-2,5-dione fused at positions-3,4 to a dibenzobarrelene backbone

BMC Chem. 2022 Mar 3;16(1):8. doi: 10.1186/s13065-022-00801-5.

Authors

Emmanuel Sopbué Fondjo¹, Abdou Salamou Njoya², Jean-de-Dieu Tamokou³, Giscard Doungmo⁴, Bruno Ndjakou Lenta⁵, Peter F W Simon⁶, Apollinaire Tsopmo⁷, Jules-Roger Kuiate³

Affiliations

¹ Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Republic of Cameroon. sopbue@yahoo.fr.
² Laboratory of Applied Synthetic Organic Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Republic of Cameroon.
³ Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, PO Box 067, Dschang, Republic of Cameroon.
⁴ Institut Für Anorganische Chemie, Christian-Albrechts-Universität Zu Kiel, Max-Eyth-Straße 2, 24118, Kiel, Germany.
⁵ Higher Teacher's Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon.
⁶ Polymer Chemistry Laboratory, Faculty of Live Sciences, Rhein-Waal University of Applied Sciences, Marie-Curie Straße 1, 47533, Kleve, Germany.
⁷ Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, K1S5B6, Canada.

Abstract

A new diazo derivative of a pyrrolidine-2,5-dione (8) fused at position-3,4 to a dibenzobarrelene backbone has been prepared by coupling the previously reported N-arylsuccinimid (5) precursor with aryldiazonium ion of aniline. The initial step of the reaction involved the preparation of the intermediate 9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboxylic anhydride (3) through [4 + 2]-cycloaddition between anthracene and maleic anhydride in refluxing xylene which was then condensed with para-aminophenol to give compound 5. Compounds 5 and 8 were characterized by their physical, elemental, and spectroscopic data. 2D-NMR (COSY, HSQC, and HMBC) techniques were used to confirm the structure of compound 5. Compounds 5 (MIC = 32-128 μg/mL) and 8 (MIC = 16-256 μg/mL) along with the precursor 3 (MIC = 64-128 μg/mL) displayed moderate to low antimicrobial activities against selected bacterial and fungal species when compared with those of nystatin (MIC = 0.50-2 μg/mL) and ciprofloxacin (MIC = 0.50-16 μg/mL) used as reference drugs.

Keywords: Anti-microbial activities; Azo compound; Dibenzobarrelene; N-arylsuccinimid; Phenols; Pyrrolidine.

Abstract

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