Shape memory micro-anchors with magnetic guidance for precision micro-vascular deployment

Zhihua Li; Zijian Chen; Yanan Gao; Yi Xing; Yuping Zhou; Yucheng Luo; Weihong Xu; Zhengchang Chen; Xu Gao; Kapish Gupta; Karthic Anbalakan; Lei Chen; Chuang Liu; Jian Kong; Hwa Liang Leo; Chengzhi Hu; Hanry Yu; Qiongyu Guo

doi:10.1016/j.biomaterials.2022.121426

Shape memory micro-anchors with magnetic guidance for precision micro-vascular deployment

Biomaterials. 2022 Apr:283:121426. doi: 10.1016/j.biomaterials.2022.121426. Epub 2022 Feb 22.

Authors

Zhihua Li¹, Zijian Chen², Yanan Gao¹, Yi Xing³, Yuping Zhou¹, Yucheng Luo¹, Weihong Xu¹, Zhengchang Chen¹, Xu Gao¹, Kapish Gupta⁴, Karthic Anbalakan⁵, Lei Chen¹, Chuang Liu⁶, Jian Kong⁷, Hwa Liang Leo⁵, Chengzhi Hu³, Hanry Yu⁸, Qiongyu Guo⁹

Affiliations

¹ Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
² Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China; Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
³ Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
⁴ Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore.
⁵ Department of Biomedical Engineering, National University of Singapore, Singapore, 117583, Singapore.
⁶ Cryo-EM Center, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China.
⁷ Department of Interventional Radiology, First Affiliated Hospital of Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, 518020, China.
⁸ Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore; Institute of Bioengineering and Nanotechnology, Agency for Science, Technology and Research, Singapore, 138669, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117593, Singapore; Singapore-MIT Alliance for Research and Technology, Singapore, 138602, Singapore.
⁹ Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, China. Electronic address: guoqy@sustech.edu.cn.

PMID: 35240471
DOI: 10.1016/j.biomaterials.2022.121426

Abstract

Transcatheter medical micro-devices through circulatory system show great potential for therapy but lack strategies to stably anchor them at the desired site in vascularized tissues to take actions. Here a shape memory functionalized biodegradable magnetic micro-anchor (SM²A) is developed to achieve magnetic guided endovascular localization through precisely controlled shape transformation. The SM²A comprises anisotropic polylactide-based microparticle embedded with superparamagnetic Fe₃O₄ nanoparticles, exhibiting thermally activated tunable shape recovery modes at a body-friendly temperature range to accomplished an efficient endovascular anchoring effect in both decellularized liver organ and rabbit ear embolization models. The SM²A can be anchored at the target micro-vessel, exhibiting a controlled radial expansion of the vessel wall yielding with estimated stresses of 7-26 kPa in contact stress and 38-218 kPa in von Mises stress. The SM²A is a promising platform to incorporate diagnostic or therapeutic agents for precision deployment and in-situ action.

Keywords: Embolotherapy; Hyperthermia; Magnetic guidance; Micro-device; Shape memory polymer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Embolization, Therapeutic*
Magnetic Phenomena
Nanoparticles*
Physical Phenomena
Rabbits