Taking a deep breath: How a brainstem pathway integrates pain and breathing

Justin Burdge; Z Anissa Jhumka; Isabel M Bravo; Ishmail Abdus-Saboor

doi:10.1016/j.neuron.2022.02.003

Taking a deep breath: How a brainstem pathway integrates pain and breathing

Neuron. 2022 Mar 2;110(5):739-741. doi: 10.1016/j.neuron.2022.02.003.

Authors

Justin Burdge¹, Z Anissa Jhumka¹, Isabel M Bravo¹, Ishmail Abdus-Saboor²

Affiliations

¹ Zuckerman Mind Brain Behavior Institute and Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
² Zuckerman Mind Brain Behavior Institute and Department of Biological Sciences, Columbia University, New York, NY 10027, USA. Electronic address: ia2458@columbia.edu.

PMID: 35240061
DOI: 10.1016/j.neuron.2022.02.003

Abstract

In this issue of Neuron, Liu et al. (2022) shed light on the neural circuits supporting pain- and anxiety-induced elevated breathing rhythms. They reveal PBL core-Oprm1 neurons projecting onto the CeA and shell-Oprm1 neurons projecting onto the preBötC as differential regulators of these behaviors.

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MeSH terms

Brain Stem
Humans
Neurons / physiology
Pain / metabolism
Respiration*
Respiratory Center* / physiology