A real use case of semi-supervised learning for mammogram classification in a local clinic of Costa Rica

Abstract

The implementation of deep learning-based computer-aided diagnosis systems for the classification of mammogram images can help in improving the accuracy, reliability, and cost of diagnosing patients. However, training a deep learning model requires a considerable amount of labelled images, which can be expensive to obtain as time and effort from clinical practitioners are required. To address this, a number of publicly available datasets have been built with data from different hospitals and clinics, which can be used to pre-train the model. However, using models trained on these datasets for later transfer learning and model fine-tuning with images sampled from a different hospital or clinic might result in lower performance. This is due to the distribution mismatch of the datasets, which include different patient populations and image acquisition protocols. In this work, a real-world scenario is evaluated where a novel target dataset sampled from a private Costa Rican clinic is used, with few labels and heavily imbalanced data. The use of two popular and publicly available datasets (INbreast and CBIS-DDSM) as source data, to train and test the models on the novel target dataset, is evaluated. A common approach to further improve the model's performance under such small labelled target dataset setting is data augmentation. However, often cheaper unlabelled data is available from the target clinic. Therefore, semi-supervised deep learning, which leverages both labelled and unlabelled data, can be used in such conditions. In this work, we evaluate the semi-supervised deep learning approach known as MixMatch, to take advantage of unlabelled data from the target dataset, for whole mammogram image classification. We compare the usage of semi-supervised learning on its own, and combined with transfer learning (from a source mammogram dataset) with data augmentation, as also against regular supervised learning with transfer learning and data augmentation from source datasets. It is shown that the use of a semi-supervised deep learning combined with transfer learning and data augmentation can provide a meaningful advantage when using scarce labelled observations. Also, we found a strong influence of the source dataset, which suggests a more data-centric approach needed to tackle the challenge of scarcely labelled data. We used several different metrics to assess the performance gain of using semi-supervised learning, when dealing with very imbalanced test datasets (such as the G-mean and the F2-score), as mammogram datasets are often very imbalanced. Graphical Abstract Description of the test-bed implemented in this work. Two different source data distributions were used to fine-tune the different models tested in this work. The target dataset is the in-house CR-Chavarria-2020 dataset.

Keywords: Breast cancer; Data imbalance; Mammogram; Semi-supervised deep learning; Transfer learning.