Effects of high fructose corn syrup on intestinal microbiota structure and obesity in mice

Xiaorong Wang; Liying Zhu; Xiaoqiong Li; Xin Wang; Ruirong Hao; Jinjun Li

doi:10.1038/s41538-022-00133-7

Effects of high fructose corn syrup on intestinal microbiota structure and obesity in mice

NPJ Sci Food. 2022 Mar 2;6(1):17. doi: 10.1038/s41538-022-00133-7.

Authors

Xiaorong Wang^{1

2}, Liying Zhu², Xiaoqiong Li², Xin Wang^{2

3}, Ruirong Hao⁴, Jinjun Li⁵

Affiliations

¹ College of Animal Science, Shanxi Agricultural University, Taigu, 030801, P. R. China.
² Institute of Food Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, P. R. China.
³ State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, P. R. China.
⁴ College of Animal Science, Shanxi Agricultural University, Taigu, 030801, P. R. China. hrr823229@126.com.
⁵ Institute of Food Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, P. R. China. lijinjun@zaas.ac.cn.

Abstract

High fructose corn syrup (HFCS)-associated health problems have raised concerns. We investigated the effects of HFCS-containing drinking water on body fat, intestinal microbiota structure of mice, and the relationships between them. HFCS drinking water significantly increased body fat content and altered the intestinal microbiome. The Christensenellaceae R-7 group negatively correlated with body weight, perirenal fat, epididymal fat, and liver fat percentage.