Piceatannol, a metabolite of resveratrol, attenuates atopic dermatitis by targeting Janus kinase 1

Chang Hyung Lee; Hee Yang; Jung Han Yoon Park; Jong-Eun Kim; Ki Won Lee

doi:10.1016/j.phymed.2022.153981

Piceatannol, a metabolite of resveratrol, attenuates atopic dermatitis by targeting Janus kinase 1

Phytomedicine. 2022 May:99:153981. doi: 10.1016/j.phymed.2022.153981. Epub 2022 Feb 12.

Authors

Chang Hyung Lee¹, Hee Yang², Jung Han Yoon Park², Jong-Eun Kim³, Ki Won Lee⁴

Affiliations

¹ Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Republic of Korea; Bio-MAX Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
² Bio-MAX Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.
³ Department of Food Science and Technology, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea. Electronic address: jekim14@ut.ac.kr.
⁴ Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Republic of Korea; Bio-MAX Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea; Advanced Institutes of Convergence Technology, Seoul National University, Suwon 16229, Republic of Korea. Electronic address: kiwon@snu.ac.kr.

PMID: 35235887
DOI: 10.1016/j.phymed.2022.153981

Abstract

Background: Piceatannol is a resveratrol metabolite commonly found in red wine, grapes. Several studies have investigated the immune-modulating effects of piceatannol on processes related to allergic reactions. However, the relationship between piceatannol and atopic dermatitis (AD) has not yet been reported. This study sought to investigate the effects of piceatannol in animal and cell line models.

Methods: AD-like symptoms and skin lesions were triggered by repeated topical treatment of Dermatophagoides farinae extract (DFE) on the skin of NC/Nga mice. The molecular mechanism of piceatannol was studied in the TNFα/IFNγ-induced HaCaT cell line.

Results: Piceatannol attenuated DFE-induced AD-like symptoms, as shown by skin thickness, dermatitis score, scratching time, and skin water loss. Histopathological analysis showed that piceatannol suppressed DFE-induced immune cell infiltration into the skin. These results occurred concomitantly with the downregulation of inflammatory markers, including serum and skin TARC and MDC. Piceatannol decreased phosphorylation of JAK-STAT protein in the TNFα/IFNγ-induced HaCaT cell line. A molecular docking study showed that piceatannol strongly interacts with JAK1, suggesting a possible mode of action.

Conclusion: The study results showed that piceatannol, a metabolite of resveratrol, attenuates atopic dermatitis and provide important implication of development of piceatannol as functional ingredients or therapeutic agents.

Keywords: Atopic dermatitis; JAK1; Piceatannol; Resveratrol.