Fish ACE2 is not susceptible to SARS-CoV-2

Virol Sin. 2022 Feb;37(1):142-144. doi: 10.1016/j.virs.2022.01.020. Epub 2022 Jan 20.

¹ CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
² CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
³ State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.
⁴ CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China. Electronic address: Yangxl@wh.iov.cn.

Abstract

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SARS-CoV-2 cannot use fish ACE2 to entry cells.
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Fish cell lines (EPC, CIK, BF-2) were not susceptible to SARS-CoV-2 infection.
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Proper disinfection of frozen food surfaces could prevent cold-chain transimission of SARS-CoV-2.