Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus

Abstract

1. •

   Tilorone dihydrochloride possesses robust anti-SFTSV activity in vitro and in vivo.

2. •

   Intraperitoneal administration of tilorone leads to protection against intracranial lethal challenge of SFTSV.

3. •

   The anti-SFTSV mechanism of tilorone is through stimulation of host innate immunity.

4. •

   Pre-treatment with tilorone can prevent mice from lethal SFTSV challenge.