The Role of Extracellular Non-coding RNAs in Atherosclerosis

J Cardiovasc Transl Res. 2022 Jun;15(3):477-491. doi: 10.1007/s12265-022-10218-z. Epub 2022 Mar 1.

Abstract

Atherosclerosis (AS) is a complex chronic inflammatory disease that leads to myocardial infarction, stroke, and disabling peripheral artery disease. Non-coding RNAs (ncRNAs) directly participate in various physiological processes and exhibit a wide range of biological functions. The present review discusses how different ncRNAs participate in the process of AS in various carrier forms. We focused on the role and potential mechanisms of extracellular ncRNAs in AS and examined their potential implications for clinical treatment.

Keywords: Arteriosclerotic cardiovascular disease (ASCVD); Atherosclerosis (AS); Circulation; Extracellular; Extracellular vesicles (EVs); Non-coding RNAs (ncRNAs).

Publication types

  • Review

MeSH terms

  • Atherosclerosis* / genetics
  • Humans
  • Myocardial Infarction*
  • RNA, Untranslated / genetics
  • Stroke*

Substances

  • RNA, Untranslated