Links between ectopic and abdominal fat and systemic inflammation: New insights from the SHIP-Trend study

Abstract

Background: Excessive fat accumulation in adipose tissue depots and organs such as the pancreas and the liver is associated with systemic low-grade chronic inflammation.

Aims: To investigate the association between abdominal, hepatic, and pancreatic fat and the circulating level of inflammatory biomarkers.

Methods: We used data from a subsample of the Study of Health in Pomerania (SHIP-Trend, n = 469). The plasma concentration of 37 inflammatory biomarkers was measured using the Bio-Plex-Pro™-Human-Inflammation-Panel-1. Subcutaneous and visceral adipose tissue (SAT and VAT), as well as hepatic and pancreatic fat, were determined by magnetic resonance imaging. We assessed the associations between fat content and inflammatory biomarkers using multiple linear regression.

Results: Hepatic fat was associated with MMP-2 (β -0.11), PTX3 (β -0.14), and TNFSF12 (β -0.06). Pancreatic fat was associated with sTNFR1 (β 0.15), sTNFR2 (β 0.11), and sCD163 (β 0.13). VAT and SAT were associated with sCD163 (β^VAT 0.20, β^SAT 0.16), MMP-2 (β^VAT -0.12, β^SAT -0.10), OSTCN (β^VAT -0.16, β^SAT -0.10), sTNFR1 (β^VAT 0.13, β^SAT 0.13), sTNFR2 (β^VAT 0.13, β^SA 0.12), TNFSF12 (β^VAT -0.11, β^SAT -0.08), and TNFSF14 (β^VAT 0.21, β^SAT 0.20). VAT was additionally associated with TNFSF13B (β 0.08) and CHI3L1 (β 0.07).

Conclusions: Our findings provide new insights into the involvement of hepatic and pancreatic fat on systemic inflammation.

Keywords: Hepatic steatosis; Low-grade chronic inflammation; Obesity; Pancreatic steatosis.